Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

Pharmacologic activation of stress-responsive signaling pathways provides a promising approach for ameliorating imbalances in proteostasis associated with diverse diseases. However, this approach has not been employed in vivo. Here we show, using a mouse model of myocardial ischemia/reperfusion, tha...

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Detalles Bibliográficos
Autores principales: Blackwood, Erik A., Azizi, Khalid, Thuerauf, Donna J., Paxman, Ryan J., Plate, Lars, Kelly, Jeffery W., Wiseman, R. Luke, Glembotski, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331617/
https://www.ncbi.nlm.nih.gov/pubmed/30643122
http://dx.doi.org/10.1038/s41467-018-08129-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331617/
https://www.ncbi.nlm.nih.gov/pubmed/30643122
http://dx.doi.org/10.1038/s41467-018-08129-2

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