Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein

Tetrathiomolybdate (TM) is used in the clinic for the treatment of Wilson’s disease by targeting the cellular copper efflux protein ATP7B (WLN). Interestingly, both TM and WLN are associated with the efficacy of cisplatin, a widely used anticancer drug. Herein, we show that TM induces dimerization o...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Tiantian, Chen, Wanbiao, Sheng, Yaping, Yuan, Siming, Tang, Qiaowei, Li, Gongyu, Huang, Guangming, Su, Jihu, Zhang, Xuan, Zang, Jianye, Liu, Yangzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331642/
https://www.ncbi.nlm.nih.gov/pubmed/30643139
http://dx.doi.org/10.1038/s41467-018-08102-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331642/
https://www.ncbi.nlm.nih.gov/pubmed/30643139
http://dx.doi.org/10.1038/s41467-018-08102-z

Ejemplares similares