Inhibition of CPAP–tubulin interaction prevents proliferation of centrosome‐amplified cancer cells

Centrosome amplification is a hallmark of human cancers that can trigger cancer cell invasion. To survive, cancer cells cluster amplified extra centrosomes and achieve pseudobipolar division. Here, we set out to prevent clustering of extra centrosomes. Tubulin, by interacting with the centrosomal pr...

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Detalles Bibliográficos
Autores principales: Mariappan, Aruljothi, Soni, Komal, Schorpp, Kenji, Zhao, Fan, Minakar, Amin, Zheng, Xiangdong, Mandad, Sunit, Macheleidt, Iris, Ramani, Anand, Kubelka, Tomáš, Dawidowski, Maciej, Golfmann, Kristina, Wason, Arpit, Yang, Chunhua, Simons, Judith, Schmalz, Hans‐Günther, Hyman, Anthony A, Aneja, Ritu, Ullrich, Roland, Urlaub, Henning, Odenthal, Margarete, Büttner, Reinhardt, Li, Haitao, Sattler, Michael, Hadian, Kamyar, Gopalakrishnan, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331730/
https://www.ncbi.nlm.nih.gov/pubmed/30530478
http://dx.doi.org/10.15252/embj.201899876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331730/
https://www.ncbi.nlm.nih.gov/pubmed/30530478
http://dx.doi.org/10.15252/embj.201899876

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