Cargando…

Computational Study of Protein-Ligand Unbinding for Enzyme Engineering

The computational prediction of unbinding rate constants is presently an emerging topic in drug design. However, the importance of predicting kinetic rates is not restricted to pharmaceutical applications. Many biotechnologically relevant enzymes have their efficiency limited by the binding of the s...

Descripción completa

Detalles Bibliográficos
Autores principales: Marques, Sérgio M., Bednar, David, Damborsky, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331733/
https://www.ncbi.nlm.nih.gov/pubmed/30671430
http://dx.doi.org/10.3389/fchem.2018.00650