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Polymorph Impact on the Bioavailability and Stability of Poorly Soluble Drugs
Drugs with low water solubility are predisposed to poor and variable oral bioavailability and, therefore, to variability in clinical response, that might be overcome through an appropriate formulation of the drug. Polymorphs (anhydrous and solvate/hydrate forms) may resolve these bioavailability pro...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331817/ https://www.ncbi.nlm.nih.gov/pubmed/26501244 http://dx.doi.org/10.3390/molecules201018759 |