A Simple, Effective, Green Method for the Regioselective 3-Acylation of Unprotected Indoles

A fast and green method is developed for regioselective acylation of indoles in the 3-position without the need for protection of the NH position. The method is based on Friedel-Crafts acylation using acid anhydrides. The method has been optimized, and Y(OTf)(3) in catalytic amounts is found to be t...

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Detalles Bibliográficos
Autores principales: Tran, Phuong Hoang, Tran, Hai Ngoc, Hansen, Poul Erik, Do, Mai Hoang Ngoc, Le, Thach Ngoc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331820/
https://www.ncbi.nlm.nih.gov/pubmed/26516834
http://dx.doi.org/10.3390/molecules201019605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331820/
https://www.ncbi.nlm.nih.gov/pubmed/26516834
http://dx.doi.org/10.3390/molecules201019605

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