Asymmetric Synthesis and Absolute Configuration Assignment of a New Type of Bedaquiline Analogue

Bedaquiline is the first FDA-approved new chemical entity to fight multidrug-resistant tuberculosis in the last forty years. Our group replaced the quinoline ring with a naphthalene ring, leading to a new type of triarylbutanol skeleton. An asymmetric synthetic route was established for our bedaquil...

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Detalles Bibliográficos
Autores principales: Qiao, Chang-Jiang, Wang, Xiao-Kui, Xie, Fei, Zhong, Wu, Li, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331863/
https://www.ncbi.nlm.nih.gov/pubmed/26690407
http://dx.doi.org/10.3390/molecules201219846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331863/
https://www.ncbi.nlm.nih.gov/pubmed/26690407
http://dx.doi.org/10.3390/molecules201219846

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