p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening

Mitogen-activated protein kinase p38α plays an essential role in the regulation of pro-inflammatory signaling, and selective blockade of this kinase could be efficacious in many pathological processes. Despite considerable research efforts focused on the discovery and development of p38α MAPK inhibi...

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Detalles Bibliográficos
Autores principales: Astolfi, Andrea, Iraci, Nunzio, Sabatini, Stefano, Barreca, Maria Letizia, Cecchetti, Violetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331920/
https://www.ncbi.nlm.nih.gov/pubmed/26334265
http://dx.doi.org/10.3390/molecules200915842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331920/
https://www.ncbi.nlm.nih.gov/pubmed/26334265
http://dx.doi.org/10.3390/molecules200915842

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