Investigating the Dissolution Performance of Amorphous Solid Dispersions Using Magnetic Resonance Imaging and Proton NMR

We have investigated the dissolution performance of amorphous solid dispersions of poorly water-soluble bicalutamide in a Kollidon VA64 polymeric matrix as a function of the drug loading (5% vs. 30% bicalutamide). A combined suite of state-of-the-art analytical techniques were employed to obtain a c...

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Detalles Bibliográficos
Autores principales: Tres, Francesco, Coombes, Steven R., Phillips, Andrew R., Hughes, Leslie P., Wren, Stephen A. C., Aylott, Jonathan W., Burley, Jonathan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331940/
https://www.ncbi.nlm.nih.gov/pubmed/26378506
http://dx.doi.org/10.3390/molecules200916404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331940/
https://www.ncbi.nlm.nih.gov/pubmed/26378506
http://dx.doi.org/10.3390/molecules200916404

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