Discovery and Structure-Based Optimization of 6-Bromotryptamine Derivatives as Potential 5-HT(2A) Receptor Antagonists

5-Hydroxytryptamine type 2A (5-HT(2A)) receptor is an important target for developing innovative antipsychotic agents in neuropsychiatric disorder therapies. To search for 5-HT(2A) receptor antagonists, a new indole alkaloid termed 6-bromo-N-propionyltryptamine (1), together with one known homologue...

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Detalles Bibliográficos
Autores principales: Ding, Lijian, He, Shan, Wu, Wei, Jin, Haixiao, Zhu, Peng, Zhang, Jinrong, Wang, Tingting, Yuan, Ye, Yan, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331983/
https://www.ncbi.nlm.nih.gov/pubmed/26404234
http://dx.doi.org/10.3390/molecules200917675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331983/
https://www.ncbi.nlm.nih.gov/pubmed/26404234
http://dx.doi.org/10.3390/molecules200917675

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