Design and Synthesis of Imidazopyrazolopyridines as Novel Selective COX-2 Inhibitors

The usefulness of non-steroidal anti-inflammatory drugs (NSAIDs) is hampered by their gastrointestinal side effects. Non-selective cyclooxygenases inhibitors interfere with both COX-1 and COX-2 isozymes. Since COX-1 mediates cytoprotection of gastric mucosa, its inhibition leads to the undesirable s...

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Detalles Bibliográficos
Autores principales: Badrey, Mohamed G., Abdel-Aziz, Hassan M., Gomha, Sobhi M., Abdalla, Mohamed M., Mayhoub, Abdelrahman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332013/
https://www.ncbi.nlm.nih.gov/pubmed/26307959
http://dx.doi.org/10.3390/molecules200815287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332013/
https://www.ncbi.nlm.nih.gov/pubmed/26307959
http://dx.doi.org/10.3390/molecules200815287

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