Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors

Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to th...

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Autores principales: Khattab, Sherine N., Khalil, Hosam H., Bekhit, Adnan A., El-Rahman, Mohamed Mokbel Abd, El-Faham, Ayman, Albericio, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332092/
https://www.ncbi.nlm.nih.gov/pubmed/26364629
http://dx.doi.org/10.3390/molecules200915976
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author Khattab, Sherine N.
Khalil, Hosam H.
Bekhit, Adnan A.
El-Rahman, Mohamed Mokbel Abd
El-Faham, Ayman
Albericio, Fernando
author_facet Khattab, Sherine N.
Khalil, Hosam H.
Bekhit, Adnan A.
El-Rahman, Mohamed Mokbel Abd
El-Faham, Ayman
Albericio, Fernando
author_sort Khattab, Sherine N.
collection PubMed
description Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity.
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spelling pubmed-63320922019-01-24 Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors Khattab, Sherine N. Khalil, Hosam H. Bekhit, Adnan A. El-Rahman, Mohamed Mokbel Abd El-Faham, Ayman Albericio, Fernando Molecules Article Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity. MDPI 2015-09-02 /pmc/articles/PMC6332092/ /pubmed/26364629 http://dx.doi.org/10.3390/molecules200915976 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Khattab, Sherine N.
Khalil, Hosam H.
Bekhit, Adnan A.
El-Rahman, Mohamed Mokbel Abd
El-Faham, Ayman
Albericio, Fernando
Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors
title Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors
title_full Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors
title_fullStr Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors
title_full_unstemmed Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors
title_short Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors
title_sort synthesis and preliminary biological evaluation of 1,3,5-triazine amino acid derivatives to study their mao inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332092/
https://www.ncbi.nlm.nih.gov/pubmed/26364629
http://dx.doi.org/10.3390/molecules200915976
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