New Polymorphic Forms of Pemetrexed Diacid and Their Use for the Preparation of Pharmaceutically Pure Amorphous and Hemipentahydrate Forms of Pemetrexed Disodium

The preparation of stable amorphous pemetrexed disodium of pharmaceutical purity as well as the process optimization for the preparation of the hemipentahydrate form of pemetrexed disodium are described. Analytical methods for the polymorphic and chemical purity studies of pemetrexed disodium and pe...

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Detalles Bibliográficos
Autores principales: Michalak, Olga, Łaszcz, Marta, Jatczak, Kamil, Witkowska, Anna, Bujak, Iwona, Groman, Aleksandra, Cybulski, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332103/
https://www.ncbi.nlm.nih.gov/pubmed/26263958
http://dx.doi.org/10.3390/molecules200813814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332103/
https://www.ncbi.nlm.nih.gov/pubmed/26263958
http://dx.doi.org/10.3390/molecules200813814

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