Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1

The human 8-oxoguanine DNA glycosylase OGG1 is involved in base excision repair (BER), one of several DNA repair mechanisms that may counteract the effects of chemo- and radiation therapy for the treatment of cancer. We envisage that potent inhibitors of OGG1 may be found among the 9-alkyl-8-oxoguan...

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Detalles Bibliográficos
Autores principales: Mahajan, Tushar R., Ytre-Arne, Mari Eknes, Strøm-Andersen, Pernille, Dalhus, Bjørn, Gundersen, Lise-Lotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332111/
https://www.ncbi.nlm.nih.gov/pubmed/26364627
http://dx.doi.org/10.3390/molecules200915944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332111/
https://www.ncbi.nlm.nih.gov/pubmed/26364627
http://dx.doi.org/10.3390/molecules200915944

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