Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole N-Oxide Leads to Reduced Mesocestoides vogae Infection Burden in Mice

Parasitic flatworms cause serious infectious diseases that affect humans and livestock in vast regions of the world, yet there are few effective drugs to treat them. Thioredoxin glutathione reductase (TGR) is an essential enzyme for redox homeostasis in flatworm parasites and a promising pharmacolog...

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Detalles Bibliográficos
Autores principales: Pasquet, Vivian, Bisio, Hugo, López, Gloria V., Romanelli-Cedrez, Laura, Bonilla, Mariana, Saldaña, Jenny, Salinas, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332120/
https://www.ncbi.nlm.nih.gov/pubmed/26132905
http://dx.doi.org/10.3390/molecules200711793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332120/
https://www.ncbi.nlm.nih.gov/pubmed/26132905
http://dx.doi.org/10.3390/molecules200711793

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