Amphiphilic Lipopeptide-Mediated Transport of Insulin and Cell Membrane Penetration Mechanism

Arginine octamer (R8) and its derivatives were developed in this study for the enhanced mucosal permeation of insulin. R8 was substituted with different aminos, then modified with stearic acid (SA). We found that the SAR6EW-insulin complex had stronger intermolecular interactions and higher complex...

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Detalles Bibliográficos
Autores principales: Zhang, Yu, Li, Lei, Han, Mei, Hu, Jiaoyin, Zhang, Liefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332136/
https://www.ncbi.nlm.nih.gov/pubmed/26633348
http://dx.doi.org/10.3390/molecules201219771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332136/
https://www.ncbi.nlm.nih.gov/pubmed/26633348
http://dx.doi.org/10.3390/molecules201219771

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