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Amphiphilic Lipopeptide-Mediated Transport of Insulin and Cell Membrane Penetration Mechanism
Arginine octamer (R8) and its derivatives were developed in this study for the enhanced mucosal permeation of insulin. R8 was substituted with different aminos, then modified with stearic acid (SA). We found that the SAR6EW-insulin complex had stronger intermolecular interactions and higher complex...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332136/ https://www.ncbi.nlm.nih.gov/pubmed/26633348 http://dx.doi.org/10.3390/molecules201219771 |