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New 1H-Benzo[f]indazole-4,9-diones Conjugated with C-Protected Amino Acids and Other Derivatives: Synthesis and in Vitro Antiproliferative Evaluation

1H-Benzo[f]indazole-4,9-dione derivatives conjugated with C-protected amino acids (glycine, l-alanine, l-phenylalanine and l-glutamic acid) 6a–l were prepared by chemically modifying the prenyl substituent of 3-methyl-7-(4-methylpent-3-enyl)-1H-benzo[f]indazole-4,9-dione 2 through epoxidation, degra...

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Detalles Bibliográficos
Autores principales: Molinari, Aurora, Oliva, Alfonso, Arismendi-Macuer, Marlene, Guzmán, Leda, Fuentealba, Mauricio, Knox, Marcela, Vinet, Raúl, San Feliciano, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332180/
https://www.ncbi.nlm.nih.gov/pubmed/26670225
http://dx.doi.org/10.3390/molecules201219809