Synthesis, Structural Studies and Molecular Modelling of a Novel Imidazoline Derivative with Antifungal Activity

Six novel imidazoline derivatives were synthesized and tested in antifungal assays. One of the compounds, N-cyclohexyl-2-imino-3-(4-nitrophenyl)imidazolidine-1-carboxamide showed moderate activity against several clinical strains of Candida albicans. Its structure was solved by X-ray crystallography...

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Detalles Bibliográficos
Autores principales: Wróbel, Tomasz M., Kosikowska, Urszula, Kaczor, Agnieszka A., Andrzejczuk, Sylwia, Karczmarzyk, Zbigniew, Wysocki, Waldemar, Urbańczyk-Lipkowska, Zofia, Morawiak, Maja, Matosiuk, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332182/
https://www.ncbi.nlm.nih.gov/pubmed/26287137
http://dx.doi.org/10.3390/molecules200814761
Descripción
Sumario:Six novel imidazoline derivatives were synthesized and tested in antifungal assays. One of the compounds, N-cyclohexyl-2-imino-3-(4-nitrophenyl)imidazolidine-1-carboxamide showed moderate activity against several clinical strains of Candida albicans. Its structure was solved by X-ray crystallography and its mode of action was deduced using molecular modelling. It was found to be similar to that of fluconazole. The potential for further optimization including SAR of the compound is briefly discussed.

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