Synthesis of C3/C1-Substituted Tetrahydroisoquinolines

A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada scoparia leaves against a panel of human and parasitic proteases revealed an interesting activity profile of 2 towards human 20S proteasome. This outcome suggests that the 1,2,3,4-tetrahydroisoquinol...

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Detalles Bibliográficos
Autores principales: Mihoubi, Mohamed, Micale, Nicola, Scala, Angela, Jarraya, Raoudha Mezghani, Bouaziz, Amira, Schirmeister, Tanja, Risitano, Francesco, Piperno, Anna, Grassi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332194/
https://www.ncbi.nlm.nih.gov/pubmed/26287146
http://dx.doi.org/10.3390/molecules200814902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332194/
https://www.ncbi.nlm.nih.gov/pubmed/26287146
http://dx.doi.org/10.3390/molecules200814902

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