Cargando…

Synthesis of C3/C1-Substituted Tetrahydroisoquinolines

A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada scoparia leaves against a panel of human and parasitic proteases revealed an interesting activity profile of 2 towards human 20S proteasome. This outcome suggests that the 1,2,3,4-tetrahydroisoquinol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mihoubi, Mohamed, Micale, Nicola, Scala, Angela, Jarraya, Raoudha Mezghani, Bouaziz, Amira, Schirmeister, Tanja, Risitano, Francesco, Piperno, Anna, Grassi, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332194/ https://www.ncbi.nlm.nih.gov/pubmed/26287146 http://dx.doi.org/10.3390/molecules200814902

Ejemplares similares

N-Methylisosalsoline from Hammada scoparia
por: Jarraya, Raoudha Mezghani, et al.
Publicado: (2008)

N-(Hydroxymethyl)ibogaine
por: Jarraya, Raoudha Mezghani, et al.
Publicado: (2008)

Substrate controlled, regioselective carbopalladation for the one-pot synthesis of C4-substituted tetrahydroisoquinoline analogues
por: Krishna Reddy, Singarajanahalli Mundarinti, et al.
Publicado: (2020)

State of the Art on Green Route Synthesis of Gold/Silver Bimetallic Nanoparticles
por: Scala, Angela, et al.
Publicado: (2022)

Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry
por: Scala, Angela, et al.
Publicado: (2018)

Antioxidant, Hepatoprotective, and Antidepression Effects of Rumex tingitanus Extracts and Identification of a Novel Bioactive Compound
por: Mhalla, Dhekra, et al.
Publicado: (2018)

Synthesis and Contractile Activity of Substituted 1,2,3,4-Tetrahydroisoquinolines
por: Ivanov, Iliyan, et al.
Publicado: (2011)

Silica-Supported Polyphosphoric Acid in the Synthesis of 4-Substituted Tetrahydroisoquinoline Derivatives
por: Manolov, Stanimir, et al.
Publicado: (2013)

Facile Synthesis of 3-Substituted Thiazolo[2,3-α]tetrahydroisoquinolines
por: Huang, Sheng-Han, et al.
Publicado: (2021)

SARS-CoV-2 M(pro): A Potential Target for Peptidomimetics and Small-Molecule Inhibitors
por: Citarella, Andrea, et al.
Publicado: (2021)

Enantioselective synthesis of isochromans and tetrahydroisoquinolines by C–H insertion of donor/donor carbenes
por: Nickerson, Leslie A., et al.
Publicado: (2019)

Synthesis and Biological Evaluations of Ring Substituted Tetrahydroisoquinolines (THIQs) as Anti-Breast Cancer Agents
por: Eyunni, Suresh VK, et al.
Publicado: (2017)

Correction: Enantioselective synthesis of isochromans and tetrahydroisoquinolines by C–H insertion of donor/donor carbenes
por: Nickerson, Leslie A., et al.
Publicado: (2020)

Antibacterial Activity of Onopordum Espinae: Identification of Hispidulin and Dehydromelitensin-8-(4ꞌ-Hydroxy-Methacrylate)
por: Njeh, Fatma, et al.
Publicado: (2017)

Structure–Activity Relationships of 7-Substituted Dimethyltyrosine-Tetrahydroisoquinoline Opioid Peptidomimetics
por: Montgomery, Deanna, et al.
Publicado: (2019)

The Discovery of Imine Reductases and their Utilisation for the Synthesis of Tetrahydroisoquinolines
por: Cárdenas‐Fernández, Max, et al.
Publicado: (2023)

MOLLUSCICIDAL AND LARVICIDAL ACTIVITIES OF Atriplex inflata AERIAL PARTS AGAINST THE MOLLUSK Galba truncatula, INTERMEDIATE HOST OF Fasciola hepatica
por: HAMED, Néjia, et al.
Publicado: (2015)

Introduction of chirality at C1 position of 1-substituted-3,4-dihydroisoquinoline by its enantioselective reduction: synthesis of chiral 1-substituted-1,2,3,4-tetrahydroisoquinoline – a review
por: Asif, Md. Moaz Ahmed, et al.
Publicado: (2023)

Recent Advances in SARS-CoV-2 Main Protease Inhibitors: From Nirmatrelvir to Future Perspectives
por: Citarella, Andrea, et al.
Publicado: (2023)

Synthesis, Characterization, and Crystal Structure of Some New Tetrahydroisoquinolines and Related Tetrahydrothieno[2,3-c]isoquinolines
por: Marae, Islam S., et al.
Publicado: (2021)

One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines
por: Sangster, Jack J., et al.
Publicado: (2023)

Synthesis of new substituted 7,12-dihydro-6,12-methanodibenzo[c,f]azocine-5-carboxylic acids containing a tetracyclic tetrahydroisoquinoline core structure
por: Grajewska, Agnieszka, et al.
Publicado: (2021)

One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues
por: Zhao, Jianxiong, et al.
Publicado: (2018)

Synthesis of 1-(para-methoxyphenyl)tetrazolyl-Substituted 1,2,3,4-Tetrahydroisoquinolines and Their Transformations Involving Activated Alkynes
por: Titov, Alexander A., et al.
Publicado: (2018)

HESI-MS/MS Analysis of Phenolic Compounds from Calendula aegyptiaca Fruits Extracts and Evaluation of Their Antioxidant Activities
por: Grati, Wafa, et al.
Publicado: (2022)

A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids
por: Pyne, Michael E., et al.
Publicado: (2020)

Recent Advances in the Total Synthesis of the Tetrahydroisoquinoline Alkaloids (2002–2020)
por: Kim, Alexia N., et al.
Publicado: (2023)

ESI-MS/MS Analysis of Phenolic Compounds from Aeonium arboreum Leaf Extracts and Evaluation of their Antioxidant and Antimicrobial Activities
por: Affes, Sahar, et al.
Publicado: (2021)

Computational Design, Synthesis, and Biophysical Evaluation of β-Amido Boronic Acids as SARS-CoV-2 M(pro) Inhibitors
por: Fassi, Enrico M. A., et al.
Publicado: (2023)

One-pot functionalisation of N-substituted tetrahydroisoquinolines by photooxidation and tunable organometallic trapping of iminium intermediates
por: Barham, Joshua P, et al.
Publicado: (2014)

Antioxidant and Antimicrobial Activities of Erodium arborescens Aerial Part Extracts and Characterization by LC-HESI-MS(2) of Its Acetone Extract
por: Samet, Sonda, et al.
Publicado: (2022)

Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Bearing a Pyrazole Scaffold and a Cinnamoyl Linker
por: Zagni, Chiara, et al.
Publicado: (2019)

Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis
por: Lu, Guo-Liang, et al.
Publicado: (2020)

Asymmetric Synthesis of Tetrahydroisoquinoline Derivatives through 1,3-Dipolar Cycloaddition of C,N-Cyclic Azomethine Imines with Allyl Alkyl Ketones
por: Feng, Guipeng, et al.
Publicado: (2021)

Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms
por: Surh, Young-Joon, et al.
Publicado: (2010)

Antiproliferative Properties of a Few Auranofin-Related Gold(I) and Silver(I) Complexes in Leukemia Cells and their Interferences with the Ubiquitin Proteasome System
por: Cirri, Damiano, et al.
Publicado: (2020)

Enzymatic and Chemoenzymatic Three‐Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines
por: Erdmann, Vanessa, et al.
Publicado: (2017)

Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells
por: Nasri, Imen, et al.
Publicado: (2016)

Concise synthesis of α-cyano tetrahydroisoquinolines with a quaternary center via Strecker reaction
por: Ji, Yue, et al.
Publicado: (2021)

Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors
por: Leese, Mathew P., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_eaqfgaopso761je5m8qlslcfhn