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Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells

Quercetin, catechins and proanthocyanidins are flavonoids that are prominently featured in foodstuffs and dietary supplements, and may possess anti-carcinogenic activity. Glioblastoma multiforme is the most dangerous form of glioma, a malignancy of the brain connective tissue. This review assesses m...

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Detalles Bibliográficos
Autores principales: Vidak, Marko, Rozman, Damjana, Komel, Radovan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332278/
https://www.ncbi.nlm.nih.gov/pubmed/26512639
http://dx.doi.org/10.3390/molecules201019406
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author Vidak, Marko
Rozman, Damjana
Komel, Radovan
author_facet Vidak, Marko
Rozman, Damjana
Komel, Radovan
author_sort Vidak, Marko
collection PubMed
description Quercetin, catechins and proanthocyanidins are flavonoids that are prominently featured in foodstuffs and dietary supplements, and may possess anti-carcinogenic activity. Glioblastoma multiforme is the most dangerous form of glioma, a malignancy of the brain connective tissue. This review assesses molecular structures of these flavonoids, their importance as components of diet and dietary supplements, their bioavailability and ability to cross the blood-brain barrier, their reported beneficial health effects, and their effects on non-malignant glial as well as glioblastoma tumor cells. The reviewed flavonoids appear to protect glial cells via reduction of oxidative stress, while some also attenuate glutamate-induced excitotoxicity and reduce neuroinflammation. Most of the reviewed flavonoids inhibit proliferation of glioblastoma cells and induce their death. Moreover, some of them inhibit pro-oncogene signaling pathways and intensify the effect of conventional anti-cancer therapies. However, most of these anti-glioblastoma effects have only been observed in vitro or in animal models. Due to limited ability of the reviewed flavonoids to access the brain, their normal dietary intake is likely insufficient to produce significant anti-cancer effects in this organ, and supplementation is needed.
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spelling pubmed-63322782019-01-24 Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells Vidak, Marko Rozman, Damjana Komel, Radovan Molecules Review Quercetin, catechins and proanthocyanidins are flavonoids that are prominently featured in foodstuffs and dietary supplements, and may possess anti-carcinogenic activity. Glioblastoma multiforme is the most dangerous form of glioma, a malignancy of the brain connective tissue. This review assesses molecular structures of these flavonoids, their importance as components of diet and dietary supplements, their bioavailability and ability to cross the blood-brain barrier, their reported beneficial health effects, and their effects on non-malignant glial as well as glioblastoma tumor cells. The reviewed flavonoids appear to protect glial cells via reduction of oxidative stress, while some also attenuate glutamate-induced excitotoxicity and reduce neuroinflammation. Most of the reviewed flavonoids inhibit proliferation of glioblastoma cells and induce their death. Moreover, some of them inhibit pro-oncogene signaling pathways and intensify the effect of conventional anti-cancer therapies. However, most of these anti-glioblastoma effects have only been observed in vitro or in animal models. Due to limited ability of the reviewed flavonoids to access the brain, their normal dietary intake is likely insufficient to produce significant anti-cancer effects in this organ, and supplementation is needed. MDPI 2015-10-23 /pmc/articles/PMC6332278/ /pubmed/26512639 http://dx.doi.org/10.3390/molecules201019406 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vidak, Marko
Rozman, Damjana
Komel, Radovan
Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells
title Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells
title_full Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells
title_fullStr Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells
title_full_unstemmed Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells
title_short Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells
title_sort effects of flavonoids from food and dietary supplements on glial and glioblastoma multiforme cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332278/
https://www.ncbi.nlm.nih.gov/pubmed/26512639
http://dx.doi.org/10.3390/molecules201019406
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