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Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells
Quercetin, catechins and proanthocyanidins are flavonoids that are prominently featured in foodstuffs and dietary supplements, and may possess anti-carcinogenic activity. Glioblastoma multiforme is the most dangerous form of glioma, a malignancy of the brain connective tissue. This review assesses m...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332278/ https://www.ncbi.nlm.nih.gov/pubmed/26512639 http://dx.doi.org/10.3390/molecules201019406 |
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author | Vidak, Marko Rozman, Damjana Komel, Radovan |
author_facet | Vidak, Marko Rozman, Damjana Komel, Radovan |
author_sort | Vidak, Marko |
collection | PubMed |
description | Quercetin, catechins and proanthocyanidins are flavonoids that are prominently featured in foodstuffs and dietary supplements, and may possess anti-carcinogenic activity. Glioblastoma multiforme is the most dangerous form of glioma, a malignancy of the brain connective tissue. This review assesses molecular structures of these flavonoids, their importance as components of diet and dietary supplements, their bioavailability and ability to cross the blood-brain barrier, their reported beneficial health effects, and their effects on non-malignant glial as well as glioblastoma tumor cells. The reviewed flavonoids appear to protect glial cells via reduction of oxidative stress, while some also attenuate glutamate-induced excitotoxicity and reduce neuroinflammation. Most of the reviewed flavonoids inhibit proliferation of glioblastoma cells and induce their death. Moreover, some of them inhibit pro-oncogene signaling pathways and intensify the effect of conventional anti-cancer therapies. However, most of these anti-glioblastoma effects have only been observed in vitro or in animal models. Due to limited ability of the reviewed flavonoids to access the brain, their normal dietary intake is likely insufficient to produce significant anti-cancer effects in this organ, and supplementation is needed. |
format | Online Article Text |
id | pubmed-6332278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63322782019-01-24 Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells Vidak, Marko Rozman, Damjana Komel, Radovan Molecules Review Quercetin, catechins and proanthocyanidins are flavonoids that are prominently featured in foodstuffs and dietary supplements, and may possess anti-carcinogenic activity. Glioblastoma multiforme is the most dangerous form of glioma, a malignancy of the brain connective tissue. This review assesses molecular structures of these flavonoids, their importance as components of diet and dietary supplements, their bioavailability and ability to cross the blood-brain barrier, their reported beneficial health effects, and their effects on non-malignant glial as well as glioblastoma tumor cells. The reviewed flavonoids appear to protect glial cells via reduction of oxidative stress, while some also attenuate glutamate-induced excitotoxicity and reduce neuroinflammation. Most of the reviewed flavonoids inhibit proliferation of glioblastoma cells and induce their death. Moreover, some of them inhibit pro-oncogene signaling pathways and intensify the effect of conventional anti-cancer therapies. However, most of these anti-glioblastoma effects have only been observed in vitro or in animal models. Due to limited ability of the reviewed flavonoids to access the brain, their normal dietary intake is likely insufficient to produce significant anti-cancer effects in this organ, and supplementation is needed. MDPI 2015-10-23 /pmc/articles/PMC6332278/ /pubmed/26512639 http://dx.doi.org/10.3390/molecules201019406 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vidak, Marko Rozman, Damjana Komel, Radovan Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells |
title | Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells |
title_full | Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells |
title_fullStr | Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells |
title_full_unstemmed | Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells |
title_short | Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells |
title_sort | effects of flavonoids from food and dietary supplements on glial and glioblastoma multiforme cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332278/ https://www.ncbi.nlm.nih.gov/pubmed/26512639 http://dx.doi.org/10.3390/molecules201019406 |
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