Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics

The protein–protein interaction (PPI) target class is particularly challenging, but offers potential for “first in class” therapies. Most known PPI small molecules are orthosteric inhibitors but many PPI sites may be fundamentally intractable to this approach. One potential alternative is to conside...

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Detalles Bibliográficos
Autores principales: Cossins, Benjamin P., Lawson, Alastair D. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332300/
https://www.ncbi.nlm.nih.gov/pubmed/26378508
http://dx.doi.org/10.3390/molecules200916435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332300/
https://www.ncbi.nlm.nih.gov/pubmed/26378508
http://dx.doi.org/10.3390/molecules200916435

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