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Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics
The protein–protein interaction (PPI) target class is particularly challenging, but offers potential for “first in class” therapies. Most known PPI small molecules are orthosteric inhibitors but many PPI sites may be fundamentally intractable to this approach. One potential alternative is to conside...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332300/ https://www.ncbi.nlm.nih.gov/pubmed/26378508 http://dx.doi.org/10.3390/molecules200916435 |