Integrase Inhibitor Prodrugs: Approaches to Enhancing the Anti-HIV Activity of β-Diketo Acids

HIV integrase, encoded at the 3′-end of the HIV pol gene, is essential for HIV replication. This enzyme catalyzes the incorporation of HIV DNA into human DNA, which represents the point of “no-return” in HIV infection. Integrase is a significant target in anti-HIV drug discovery. This review article...

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Detalles Bibliográficos
Autores principales: Nair, Vasu, Okello, Maurice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332332/
https://www.ncbi.nlm.nih.gov/pubmed/26184144
http://dx.doi.org/10.3390/molecules200712623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332332/
https://www.ncbi.nlm.nih.gov/pubmed/26184144
http://dx.doi.org/10.3390/molecules200712623

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