3-H-[1,2]Dithiole as a New Anti-Trypanosoma cruzi Chemotype: Biological and Mechanism of Action Studies

The current pharmacological Chagas disease treatments, using Nifurtimox or Benznidazole, show limited therapeutic results and are associated with potential side effects, like mutagenicity. Using random screening we have identified new chemotypes that were able to inhibit relevant targets of the Tryp...

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Detalles Bibliográficos
Autores principales: Couto, Marcos, Sánchez, Carina, Dávila, Belén, Machín, Valentina, Varela, Javier, Álvarez, Guzmán, Cabrera, Mauricio, Celano, Laura, Aguirre-López, Beatriz, Cabrera, Nallely, Tuena de Gómez-Puyou, Marieta, Gómez-Puyou, Armando, Pérez-Montfort, Ruy, Cerecetto, Hugo, González, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332334/
https://www.ncbi.nlm.nih.gov/pubmed/26274947
http://dx.doi.org/10.3390/molecules200814595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332334/
https://www.ncbi.nlm.nih.gov/pubmed/26274947
http://dx.doi.org/10.3390/molecules200814595

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