Cargando…

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone and Thymoquinone in a Rat Model of Brain Ischemia/Reperfusion Injury

We explored the neuroprotective properties of natural plant-derived antioxidants plastoquinone and thymoquinone (2-demethylplastoquinone derivative) modified to be specifically accumulated in mitochondria. The modification was performed through chemical conjugation of the quinones with penetrating c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Silachev, Denis N., Plotnikov, Egor Y., Zorova, Ljubava D., Pevzner, Irina B., Sumbatyan, Natalia V., Korshunova, Galina A., Gulyaev, Mikhail V., Pirogov, Yury A., Skulachev, Vladimir P., Zorov, Dmitry B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332348/ https://www.ncbi.nlm.nih.gov/pubmed/26270657 http://dx.doi.org/10.3390/molecules200814487

Ejemplares similares

Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic–Ischemic Brain Injury
por: Silachev, Denis N., et al.
Publicado: (2018)

Neuroprotective Potential of Mild Uncoupling in Mitochondria. Pros and Cons
por: Zorov, Dmitry B., et al.
Publicado: (2021)

The Mitochondria-Targeted Antioxidants and Remote Kidney Preconditioning Ameliorate Brain Damage through Kidney-to-Brain Cross-Talk
por: Silachev, Denis N., et al.
Publicado: (2012)

Mitochondrial Damage and Mitochondria-Targeted Antioxidant Protection in LPS-Induced Acute Kidney Injury
por: Plotnikov, Egor Y., et al.
Publicado: (2019)

Miro1 Enhances Mitochondria Transfer from Multipotent Mesenchymal Stem Cells (MMSC) to Neural Cells and Improves the Efficacy of Cell Recovery
por: Babenko, Valentina A., et al.
Publicado: (2018)

Is the Mitochondrial Membrane Potential (∆Ψ) Correctly Assessed? Intracellular and Intramitochondrial Modifications of the ∆Ψ Probe, Rhodamine 123
por: Zorova, Ljubava D., et al.
Publicado: (2022)

Mechanisms of Age-Dependent Loss of Dietary Restriction Protective Effects in Acute Kidney Injury
por: Andrianova, Nadezda V., et al.
Publicado: (2018)

Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats
por: Andrianova, Nadezda V., et al.
Publicado: (2020)

Age-Associated Loss in Renal Nestin-Positive Progenitor Cells
por: Buyan, Marina I., et al.
Publicado: (2022)

Calorie Restriction Provides Kidney Ischemic Tolerance in Senescence-Accelerated OXYS Rats
por: Andrianova, Nadezda V., et al.
Publicado: (2022)

Mechanisms of LPS-Induced Acute Kidney Injury in Neonatal and Adult Rats
por: Plotnikov, Egor Y., et al.
Publicado: (2018)

Pregnancy protects the kidney from acute ischemic injury
por: Popkov, Vasily A., et al.
Publicado: (2018)

The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy
por: Jankauskas, Stanislovas S., et al.
Publicado: (2017)

Lessons from the Discovery of Mitochondrial Fragmentation (Fission): A Review and Update
por: Zorov, Dmitry B., et al.
Publicado: (2019)

Kidney Cells Regeneration: Dedifferentiation of Tubular Epithelium, Resident Stem Cells and Possible Niches for Renal Progenitors
por: Andrianova, Nadezda V., et al.
Publicado: (2019)

Mitochondrial ATP Synthase and Mild Uncoupling by Butyl Ester of Rhodamine 19, C4R1
por: Zorova, Ljubava D., et al.
Publicado: (2023)

Age-Related Changes in Bone-Marrow Mesenchymal Stem Cells
por: Babenko, Valentina A., et al.
Publicado: (2021)

Microbiome-Metabolome Signature of Acute Kidney Injury
por: Andrianova, Nadezda V., et al.
Publicado: (2020)

Do Extracellular Vesicles Derived from Mesenchymal Stem Cells Contain Functional Mitochondria?
por: Zorova, Ljubava D., et al.
Publicado: (2022)

Development of an In Vitro Model of SARS-CoV-Induced Acute Lung Injury for Studying New Therapeutic Approaches
por: Shevtsova, Yulia A., et al.
Publicado: (2022)

Mesenchymal stromal cell-derived extracellular vesicles afford neuroprotection by modulating PI3K/AKT pathway and calcium oscillations
por: Turovsky, Egor A., et al.
Publicado: (2022)

Fibrosis Development Linked to Alterations in Glucose and Energy Metabolism and Prooxidant–Antioxidant Balance in Experimental Models of Liver Injury
por: Semenovich, Dmitry S., et al.
Publicado: (2023)

Mitochondria as a Source and a Target for Uremic Toxins
por: Popkov, Vasily A., et al.
Publicado: (2019)

Effects of Recombinant Spidroin rS1/9 on Brain Neural Progenitors After Photothrombosis-Induced Ischemia
por: Moisenovich, Mikhail M., et al.
Publicado: (2020)

Pros and Cons of Use of Mitochondria-Targeted Antioxidants
por: Plotnikov, Egor Y., et al.
Publicado: (2019)

Effect of MSCs and MSC-Derived Extracellular Vesicles on Human Blood Coagulation
por: Silachev, Denis N., et al.
Publicado: (2019)

Mitochondria in the Nuclei of Rat Myocardial Cells
por: Eldarov, Chupalav M., et al.
Publicado: (2020)

Mitochondria-targeted antioxidants as highly effective antibiotics
por: Nazarov, Pavel A., et al.
Publicado: (2017)

Effects of caloric restriction and ketogenic diet on renal fibrosis after ischemia/reperfusion injury
por: Yakupova, E.I., et al.
Publicado: (2023)

Decreased renal expression of PAQR5 is associated with the absence of a nephroprotective effect of progesterone in a rat UUO model
por: Abramicheva, P. A., et al.
Publicado: (2023)

The Neuroprotective Effects of Thymoquinone: A Review
por: Farkhondeh, Tahereh, et al.
Publicado: (2018)

Editorial: Mitochondria in Renal Health and Disease
por: Plotnikov, Egor, et al.
Publicado: (2021)

The plastoquinone pool, poised for cyclic electron flow?
por: Alric, Jean
Publicado: (2015)

Evaluation of Neuroprotective Effect of Thymoquinone Nanoformulation in the Rodent Cerebral Ischemia-Reperfusion Model
por: Xiao, Xiao-Yu, et al.
Publicado: (2016)

Editorial: Mitochondria in Renal Health and Disease, Volume II
por: Plotnikov, Egor, et al.
Publicado: (2022)

Exchange pathways of plastoquinone and plastoquinol in the photosystem II complex
por: Van Eerden, Floris J., et al.
Publicado: (2017)

Dietary Restriction for Kidney Protection: Decline in Nephroprotective Mechanisms During Aging
por: Andrianova, Nadezda V., et al.
Publicado: (2021)

Structure/Function/Dynamics of Photosystem II Plastoquinone Binding Sites
por: Lambreva, Maya D., et al.
Publicado: (2014)

Plastoquinone and Ubiquinone in Plants: Biosynthesis, Physiological Function and Metabolic Engineering
por: Liu, Miaomiao, et al.
Publicado: (2016)

Redox potentials of ubiquinone, menaquinone, phylloquinone, and plastoquinone in aqueous solution
por: Kishi, Shinnosuke, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_u7jviftp0498n41r9l494s39al