Synthesis, Biological Evaluation and Molecular Docking Studies of Piperidinylpiperidines and Spirochromanones Possessing Quinoline Moieties as Acetyl-CoA Carboxylase Inhibitors

Acetyl-coenzyme A carboxylases (ACCs) play critical roles in the regulation of fatty acid metabolism and have been targeted for the development of drugs against obesity, diabetes and other metabolic diseases. Two series of compounds possessing quinoline moieties were designed, synthesized and evalua...

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Detalles Bibliográficos
Autores principales: Huang, Tonghui, Sun, Jie, Wang, Qianqian, Gao, Jian, Liu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332354/
https://www.ncbi.nlm.nih.gov/pubmed/26370948
http://dx.doi.org/10.3390/molecules200916221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332354/
https://www.ncbi.nlm.nih.gov/pubmed/26370948
http://dx.doi.org/10.3390/molecules200916221

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