A CuAAC–Hydrazone–CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations

We present a trifunctional scaffold designed for the solid-phase synthesis of trimodal compounds. This scaffold holds two alkyne arms in a free and TIPS-protected form for consecutive CuAAC (copper(I)-catalyzed azide–alkyne cycloaddition), one Fmoc-protected hydrazide arm for reaction with aldehydes...

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Detalles Bibliográficos
Autores principales: Fabre, Benjamin, Pícha, Jan, Vaněk, Václav, Buděšínský, Miloš, Jiráček, Jiří
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332392/
https://www.ncbi.nlm.nih.gov/pubmed/26512633
http://dx.doi.org/10.3390/molecules201019310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332392/
https://www.ncbi.nlm.nih.gov/pubmed/26512633
http://dx.doi.org/10.3390/molecules201019310

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