X-ray Crystallography, DFT Calculations and Molecular Docking of Indole-Arylpiperazine Derivatives as α(1A)-Adrenoceptor Antagonists

Indole-arylpiperazine derivatives have exhibited good selectivity for the α(1A)-adrenoceptor, but the structure-activity-binding mechanism relationship remains unclear. In the current study, three compounds (1, 2 and 3) were investigated through single-crystal X-ray diffraction analysis, density fun...

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Detalles Bibliográficos
Autores principales: Xu, Wei, Huang, Jun-Jun, Shao, Bin-Hao, Xu, Xing-Jie, Jiang, Ren-Wang, Yuan, Mu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332402/
https://www.ncbi.nlm.nih.gov/pubmed/26528963
http://dx.doi.org/10.3390/molecules201119651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332402/
https://www.ncbi.nlm.nih.gov/pubmed/26528963
http://dx.doi.org/10.3390/molecules201119651

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