Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl

An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cycliza...

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Autores principales: Chen, Wen-Chang, Lin, Chan-Chieh, Kavala, Veerababurao, Kuo, Chun-Wei, Huang, Chia-Yu, Yao, Ching-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332431/
https://www.ncbi.nlm.nih.gov/pubmed/26694335
http://dx.doi.org/10.3390/molecules201219862
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author Chen, Wen-Chang
Lin, Chan-Chieh
Kavala, Veerababurao
Kuo, Chun-Wei
Huang, Chia-Yu
Yao, Ching-Fa
author_facet Chen, Wen-Chang
Lin, Chan-Chieh
Kavala, Veerababurao
Kuo, Chun-Wei
Huang, Chia-Yu
Yao, Ching-Fa
author_sort Chen, Wen-Chang
collection PubMed
description An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high.
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spelling pubmed-63324312019-01-24 Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl Chen, Wen-Chang Lin, Chan-Chieh Kavala, Veerababurao Kuo, Chun-Wei Huang, Chia-Yu Yao, Ching-Fa Molecules Article An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high. MDPI 2015-12-15 /pmc/articles/PMC6332431/ /pubmed/26694335 http://dx.doi.org/10.3390/molecules201219862 Text en © 2015 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Wen-Chang
Lin, Chan-Chieh
Kavala, Veerababurao
Kuo, Chun-Wei
Huang, Chia-Yu
Yao, Ching-Fa
Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl
title Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl
title_full Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl
title_fullStr Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl
title_full_unstemmed Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl
title_short Syntheses of 4-Indolylquinoline Derivatives via Reductive Cyclization of Indolylnitrochalcone Derivatives by Fe/HCl
title_sort syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by fe/hcl
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332431/
https://www.ncbi.nlm.nih.gov/pubmed/26694335
http://dx.doi.org/10.3390/molecules201219862
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