Synthesis, Hydrolysis, and Protonation-Promoted Intramolecular Reductive Breakdown of Potential NRTIs: Stavudine α-P-Borano-γ-P-N-l-tryptophanyltriphosphates

Phosphorus-modified prodrugs of dideoxynucleoside triphosphates (ddNTPs) have shown promise as pronucleotide strategies for improving antiviral activity compared to their parent dideoxynucleosides. Borane modified NTPs offer a promising choice as nucleoside/nucleotide reverse transcriptase inhibitor...

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Detalles Bibliográficos
Autores principales: Xu, Zhihong, Shaw, Barbara Ramsay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332514/
https://www.ncbi.nlm.nih.gov/pubmed/26501247
http://dx.doi.org/10.3390/molecules201018808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332514/
https://www.ncbi.nlm.nih.gov/pubmed/26501247
http://dx.doi.org/10.3390/molecules201018808

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