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CYR61 triggers osteosarcoma metastatic spreading via an IGF1Rβ-dependent EMT-like process
BACKGROUND: Osteosarcoma is the most prevalent primary bone malignancy in children and young adults. These tumors are highly metastatic, leading to poor outcome. We previously demonstrated that Cysteine-rich protein 61 (CYR61/CCN1) expression level is correlated to osteosarcoma aggressiveness in pre...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332662/ https://www.ncbi.nlm.nih.gov/pubmed/30642298 http://dx.doi.org/10.1186/s12885-019-5282-4 |