Photoactive chlorin e6 is a multifunctional modulator of amyloid-β aggregation and toxicity via specific interactions with its histidine residues

The self-assembly of Aβ to β-sheet-rich neurotoxic oligomers is a main pathological event leading to Alzheimer's disease (AD). Selective targeting of Aβ oligomers without affecting other functional proteins is therefore an attractive approach to prevent the disease and its progression. In this...

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Detalles Bibliográficos
Autores principales: Leshem, Guy, Richman, Michal, Lisniansky, Elvira, Antman-Passig, Merav, Habashi, Maram, Gräslund, Astrid, Wärmländer, Sebastian K. T. S., Rahimipour, Shai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333166/
https://www.ncbi.nlm.nih.gov/pubmed/30713632
http://dx.doi.org/10.1039/c8sc01992d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333166/
https://www.ncbi.nlm.nih.gov/pubmed/30713632
http://dx.doi.org/10.1039/c8sc01992d

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