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A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine
Inteins remove themselves from a precursor protein by protein splicing. Due to the concomitant structural changes of the host protein, this self-processing reaction has enabled many applications in protein biotechnology and chemical biology. We show that the evolved M86 mutant of the Ssp DnaB intein...
Autores principales: | Friedel, Kristina, Popp, Monika A., Matern, Julian C. J., Gazdag, Emerich M., Thiel, Ilka V., Volkmann, Gerrit, Blankenfeldt, Wulf, Mootz, Henning D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333167/ https://www.ncbi.nlm.nih.gov/pubmed/30713635 http://dx.doi.org/10.1039/c8sc01074a |
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