Cdt1 variants reveal unanticipated aspects of interactions with cyclin/CDK and MCM important for normal genome replication

The earliest step in DNA replication is origin licensing, which is the DNA loading of minichromosome maintenance (MCM) helicase complexes. The Cdc10-dependent transcript 1 (Cdt1) protein is essential for MCM loading during the G1 phase of the cell cycle, but the mechanism of Cdt1 function is still i...

Descripción completa

Detalles Bibliográficos
Autores principales: Pozo, Pedro N., Matson, Jacob P., Cole, Yasemin, Kedziora, Katarzyna M., Grant, Gavin D., Temple, Brenda, Cook, Jeanette Gowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333176/
https://www.ncbi.nlm.nih.gov/pubmed/30281379
http://dx.doi.org/10.1091/mbc.E18-04-0242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333176/
https://www.ncbi.nlm.nih.gov/pubmed/30281379
http://dx.doi.org/10.1091/mbc.E18-04-0242

Ejemplares similares