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Cdt1 variants reveal unanticipated aspects of interactions with cyclin/CDK and MCM important for normal genome replication

The earliest step in DNA replication is origin licensing, which is the DNA loading of minichromosome maintenance (MCM) helicase complexes. The Cdc10-dependent transcript 1 (Cdt1) protein is essential for MCM loading during the G1 phase of the cell cycle, but the mechanism of Cdt1 function is still i...

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Detalles Bibliográficos
Autores principales:	Pozo, Pedro N., Matson, Jacob P., Cole, Yasemin, Kedziora, Katarzyna M., Grant, Gavin D., Temple, Brenda, Cook, Jeanette Gowen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333176/ https://www.ncbi.nlm.nih.gov/pubmed/30281379 http://dx.doi.org/10.1091/mbc.E18-04-0242

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