Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines

A tetrakis(phenolato) Ti(iv) complex was synthesized in racemic and optically pure form, exhibiting high hydrolytic stability, and similar cytotoxicity for all stereochemical forms on HT-29 and A2780 cancer cells. Higher activity of the racemate on drug-resistant A2780cp and A2780adr lines implies a...

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Detalles Bibliográficos
Autores principales: Miller, Maya, Tshuva, Edit Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333245/
https://www.ncbi.nlm.nih.gov/pubmed/30713687
http://dx.doi.org/10.1039/c8ra08925f
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author Miller, Maya
Tshuva, Edit Y.
author_facet Miller, Maya
Tshuva, Edit Y.
author_sort Miller, Maya
collection PubMed
description A tetrakis(phenolato) Ti(iv) complex was synthesized in racemic and optically pure form, exhibiting high hydrolytic stability, and similar cytotoxicity for all stereochemical forms on HT-29 and A2780 cancer cells. Higher activity of the racemate on drug-resistant A2780cp and A2780adr lines implies a beneficial activity of both enantiomers rendering enantiomeric resolution unnecessary.
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spelling pubmed-63332452019-02-01 Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines Miller, Maya Tshuva, Edit Y. RSC Adv Chemistry A tetrakis(phenolato) Ti(iv) complex was synthesized in racemic and optically pure form, exhibiting high hydrolytic stability, and similar cytotoxicity for all stereochemical forms on HT-29 and A2780 cancer cells. Higher activity of the racemate on drug-resistant A2780cp and A2780adr lines implies a beneficial activity of both enantiomers rendering enantiomeric resolution unnecessary. The Royal Society of Chemistry 2018-11-27 /pmc/articles/PMC6333245/ /pubmed/30713687 http://dx.doi.org/10.1039/c8ra08925f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Miller, Maya
Tshuva, Edit Y.
Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines
title Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines
title_full Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines
title_fullStr Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines
title_full_unstemmed Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines
title_short Racemic vs. enantiopure inert Ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines
title_sort racemic vs. enantiopure inert ti(iv) complex of a single diaminotetrakis(phenolato) ligand in anticancer activity toward human drug-sensitive and -resistant cancer cell lines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333245/
https://www.ncbi.nlm.nih.gov/pubmed/30713687
http://dx.doi.org/10.1039/c8ra08925f
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AT tshuvaedity racemicvsenantiopureinerttiivcomplexofasinglediaminotetrakisphenolatoligandinanticanceractivitytowardhumandrugsensitiveandresistantcancercelllines

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