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Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways

AIM: To testify the hypothesis that endostatin exerts antifibrotic effects in hepatic stellate cells (HSCs) by modulating RhoA (ras homolog gene family, member A)/ROCK 1 (Rho-associated protein kinase 1) signal pathways. MATERIALS AND METHODS: HSCs-T6 of passages 3–5 were cultured in DMEM and serum...

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Detalles Bibliográficos
Autores principales: Ren, Haitao, Li, Yuan, Chen, Yan, Wang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333321/
https://www.ncbi.nlm.nih.gov/pubmed/30666090
http://dx.doi.org/10.2147/DDDT.S191617