Reiterative Enrichment and Authentication of CRISPRi Targets (REACT) identifies the proteasome as a key contributor to HIV-1 latency

The establishment of HIV-1 latency gives rise to persistent chronic infection that requires life-long treatment. To reverse latency for viral eradiation, the HIV-1 Tat protein and its associated ELL2-containing Super Elongation Complexes (ELL2-SECs) are essential to activate HIV-1 transcription. Des...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Zichong, Wu, Jun, Chavez, Leonard, Hoh, Rebecca, Deeks, Steven G., Pillai, Satish K., Zhou, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333332/
https://www.ncbi.nlm.nih.gov/pubmed/30645648
http://dx.doi.org/10.1371/journal.ppat.1007498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333332/
https://www.ncbi.nlm.nih.gov/pubmed/30645648
http://dx.doi.org/10.1371/journal.ppat.1007498

Ejemplares similares