Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection

BACKGROUND: Sterile alpha motif and histidine/aspartic acid domain-containing protein (SAMHD1) is a dNTP triphosphorylase that reduces cellular dNTP levels in non-dividing cells, such as macrophages. Since dNTPs are required for reverse transcription, HIV-2 and most SIVs encode a Vpx protein that pr...

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Detalles Bibliográficos
Autores principales: Plitnik, Timothy, Sharkey, Mark E., Mahboubi, Bijan, Kim, Baek, Stevenson, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pathogens and Immunity 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333473/
https://www.ncbi.nlm.nih.gov/pubmed/30656243
http://dx.doi.org/10.20411/pai.v3i2.263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333473/
https://www.ncbi.nlm.nih.gov/pubmed/30656243
http://dx.doi.org/10.20411/pai.v3i2.263

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