Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis

Trefoil factor 1 (TFF1, also known as pS2) is strongly expressed in the gastrointestinal mucosa and plays a critical role in the differentiation of gastric glands. Since approximately 50% of all human gastric cancers are associated with decreased TFF1 expression, it is considered a tumor suppressor...

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Detalles Bibliográficos
Autores principales: Kim, Hyejeong, Jeong, Haengdueng, Cho, Yejin, Lee, Jaehoon, Nam, Ki Taek, Lee, Han-Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333602/
https://www.ncbi.nlm.nih.gov/pubmed/30671113
http://dx.doi.org/10.5625/lar.2018.34.4.257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333602/
https://www.ncbi.nlm.nih.gov/pubmed/30671113
http://dx.doi.org/10.5625/lar.2018.34.4.257

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