CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice

CD47 (integrin-associated protein), a multi-spanning transmembrane protein expressed in all cells including red blood cells (RBCs) and leukocytes, interacts with signal regulatory protein α (SIRPα) on macrophages and thereby inhibits phagocytosis of RBCs. Recently, we generated a novel C57BL/6J CD47...

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Detalles Bibliográficos
Autores principales: Kim, Joo-Il, Park, Jin-Sung, Kwak, Jina, Lim, Hyun-Jin, Ryu, Soo-Kyung, Kwon, Euna, Han, Kang-Min, Nam, Ki-Taek, Lee, Han-Woong, Kang, Byeong-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333621/
https://www.ncbi.nlm.nih.gov/pubmed/30671119
http://dx.doi.org/10.5625/lar.2018.34.4.302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333621/
https://www.ncbi.nlm.nih.gov/pubmed/30671119
http://dx.doi.org/10.5625/lar.2018.34.4.302

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