Trodusquemine enhances Aβ(42) aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Transient oligomeric species formed during the aggregation process of the 42-residue form of the amyloid-β peptide (Aβ(42)) are key pathogenic agents in Alzheimer’s disease (AD). To investigate the relationship between Aβ(42) aggregation and its cytotoxicity and the influence of a potential drug on...

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Detalles Bibliográficos
Autores principales: Limbocker, Ryan, Chia, Sean, Ruggeri, Francesco S., Perni, Michele, Cascella, Roberta, Heller, Gabriella T., Meisl, Georg, Mannini, Benedetta, Habchi, Johnny, Michaels, Thomas C. T., Challa, Pavan K., Ahn, Minkoo, Casford, Samuel T., Fernando, Nilumi, Xu, Catherine K., Kloss, Nina D., Cohen, Samuel I. A., Kumita, Janet R., Cecchi, Cristina, Zasloff, Michael, Linse, Sara, Knowles, Tuomas P. J., Chiti, Fabrizio, Vendruscolo, Michele, Dobson, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333784/
https://www.ncbi.nlm.nih.gov/pubmed/30644384
http://dx.doi.org/10.1038/s41467-018-07699-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333784/
https://www.ncbi.nlm.nih.gov/pubmed/30644384
http://dx.doi.org/10.1038/s41467-018-07699-5

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