Prototype foamy virus intasome aggregation is mediated by outer protein domains and prevented by protocatechuic acid

The integrase (IN) enzyme of retrovirus prototype foamy virus (PFV) consists of four domains: amino terminal extension (NED), amino terminus (NTD), catalytic core (CCD), and carboxyl terminus domains (CTD). A tetramer of PFV IN with two viral DNA ends forms the functional intasome. Two inner monomer...

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Detalles Bibliográficos
Autores principales: Jones, Nathan D., Mackler, Randi M., Lopez, Miguel A., Baltierra-Jasso, Laura E., Altman, Matthew P., Senavirathne, Gayan, Yoder, Kristine E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333793/
https://www.ncbi.nlm.nih.gov/pubmed/30644416
http://dx.doi.org/10.1038/s41598-018-36725-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333793/
https://www.ncbi.nlm.nih.gov/pubmed/30644416
http://dx.doi.org/10.1038/s41598-018-36725-1

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