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Prototype foamy virus intasome aggregation is mediated by outer protein domains and prevented by protocatechuic acid
The integrase (IN) enzyme of retrovirus prototype foamy virus (PFV) consists of four domains: amino terminal extension (NED), amino terminus (NTD), catalytic core (CCD), and carboxyl terminus domains (CTD). A tetramer of PFV IN with two viral DNA ends forms the functional intasome. Two inner monomer...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333793/ https://www.ncbi.nlm.nih.gov/pubmed/30644416 http://dx.doi.org/10.1038/s41598-018-36725-1 |