Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1

CD123 (IL-3Rα) is frequently expressed by malignant Hodgkin lymphoma (HL) cells. Naked monoclonal antibodies (mAb) against HL lack clinical benefit, partially due to absence of natural killer (NK) cells in the tumor microenvironment. Here we show that the combination of a fully humanized anti-CD123...

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Detalles Bibliográficos
Autores principales: Ernst, Daniel, Williams, Brent A., Wang, Xing-Hua, Yoon, Nara, Kim, Kyung-Phil, Chiu, Jodi, Luo, Zhi Juan, Hermans, Karin G., Krueger, Joerg, Keating, Armand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333842/
https://www.ncbi.nlm.nih.gov/pubmed/30647406
http://dx.doi.org/10.1038/s41408-018-0168-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333842/
https://www.ncbi.nlm.nih.gov/pubmed/30647406
http://dx.doi.org/10.1038/s41408-018-0168-2

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