Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the therapeutic response produced by novel rapid-acting antidepressants such as ketamine are mediated by mPFC activity. The mPFC contains multiple types of pyramidal cells, but it is unclear whether a particular...

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Detalles Bibliográficos
Autores principales: Hare, Brendan D., Shinohara, Ryota, Liu, Rong Jian, Pothula, Santosh, DiLeone, Ralph J., Duman, Ronald S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333924/
https://www.ncbi.nlm.nih.gov/pubmed/30644390
http://dx.doi.org/10.1038/s41467-018-08168-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333924/
https://www.ncbi.nlm.nih.gov/pubmed/30644390
http://dx.doi.org/10.1038/s41467-018-08168-9

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