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Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects
Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the therapeutic response produced by novel rapid-acting antidepressants such as ketamine are mediated by mPFC activity. The mPFC contains multiple types of pyramidal cells, but it is unclear whether a particular...
Autores principales: | Hare, Brendan D., Shinohara, Ryota, Liu, Rong Jian, Pothula, Santosh, DiLeone, Ralph J., Duman, Ronald S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333924/ https://www.ncbi.nlm.nih.gov/pubmed/30644390 http://dx.doi.org/10.1038/s41467-018-08168-9 |
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