Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer
PURPOSE: The purpose of this study was to evaluate chemotherapy patterns and changes in quality of life (QOL) during first-line palliative chemotherapy for Korean patients with unresectable or metastatic/recurrent gastric cancer (GC). MATERIALS AND METHODS: Thiswas a non-interventional, multi-center...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Cancer Association
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333995/ https://www.ncbi.nlm.nih.gov/pubmed/30584995 http://dx.doi.org/10.4143/crt.2018.073 |
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author | Kim, Jin Won Kim, Jong Gwang Kang, Byung Woog Chung, Ik-Joo Hong, Young Seon Kim, Tae-You Song, Hong Suk Lee, Kyung Hee Zang, Dae Young Ko, Yoon Ho Song, Eun-Kee Baek, Jin Ho Koo, Dong‐Hoe Oh, So Yeon Cho, Hana Lee, Keun-Wook |
author_facet | Kim, Jin Won Kim, Jong Gwang Kang, Byung Woog Chung, Ik-Joo Hong, Young Seon Kim, Tae-You Song, Hong Suk Lee, Kyung Hee Zang, Dae Young Ko, Yoon Ho Song, Eun-Kee Baek, Jin Ho Koo, Dong‐Hoe Oh, So Yeon Cho, Hana Lee, Keun-Wook |
author_sort | Kim, Jin Won |
collection | PubMed |
description | PURPOSE: The purpose of this study was to evaluate chemotherapy patterns and changes in quality of life (QOL) during first-line palliative chemotherapy for Korean patients with unresectable or metastatic/recurrent gastric cancer (GC). MATERIALS AND METHODS: Thiswas a non-interventional, multi-center, prospective, observational study of 527 patients in Korea. QOL assessments were conducted using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaires (QLQ)-C30 and QLQ-STO22 every 3 months over a 12-month period during first-line palliative chemotherapy. The specific chemotherapy regimens were selected by individual clinicians. RESULTS: Most patients (93.2%) received combination chemotherapy (mainly fluoropyrimidine plus platinum) as their first-line palliative chemotherapy. The median progression-free survival and overall survival were 8.2 and 14.8 months, respectively. Overall, “a little” changes (differences of 5-10 points from baseline)were observed in some of the functioning or symptom scales; none of the QOL scales showed either “moderate” or “very much” change (i.e., ≥ 11 point difference from baseline). When examining the best change in each QOL domain from baseline, scales related to some aspects of functioning, global health status/QOL, and most symptoms revealed significant improvements (p < 0.05). Throughout the course of first-line palliative chemotherapy, most patients’ QOL was maintained to a similar degree, regardless of their actual response to chemotherapy. CONCLUSION: This observational study provides important information on the chemotherapy patterns and QOL changes in Korean patientswith advanced GC. Overall, first-line palliative chemotherapy was found to maintain QOL, and most parameters showed an improvement compared with the baseline at some point during the course. |
format | Online Article Text |
id | pubmed-6333995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-63339952019-01-22 Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer Kim, Jin Won Kim, Jong Gwang Kang, Byung Woog Chung, Ik-Joo Hong, Young Seon Kim, Tae-You Song, Hong Suk Lee, Kyung Hee Zang, Dae Young Ko, Yoon Ho Song, Eun-Kee Baek, Jin Ho Koo, Dong‐Hoe Oh, So Yeon Cho, Hana Lee, Keun-Wook Cancer Res Treat Original Article PURPOSE: The purpose of this study was to evaluate chemotherapy patterns and changes in quality of life (QOL) during first-line palliative chemotherapy for Korean patients with unresectable or metastatic/recurrent gastric cancer (GC). MATERIALS AND METHODS: Thiswas a non-interventional, multi-center, prospective, observational study of 527 patients in Korea. QOL assessments were conducted using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaires (QLQ)-C30 and QLQ-STO22 every 3 months over a 12-month period during first-line palliative chemotherapy. The specific chemotherapy regimens were selected by individual clinicians. RESULTS: Most patients (93.2%) received combination chemotherapy (mainly fluoropyrimidine plus platinum) as their first-line palliative chemotherapy. The median progression-free survival and overall survival were 8.2 and 14.8 months, respectively. Overall, “a little” changes (differences of 5-10 points from baseline)were observed in some of the functioning or symptom scales; none of the QOL scales showed either “moderate” or “very much” change (i.e., ≥ 11 point difference from baseline). When examining the best change in each QOL domain from baseline, scales related to some aspects of functioning, global health status/QOL, and most symptoms revealed significant improvements (p < 0.05). Throughout the course of first-line palliative chemotherapy, most patients’ QOL was maintained to a similar degree, regardless of their actual response to chemotherapy. CONCLUSION: This observational study provides important information on the chemotherapy patterns and QOL changes in Korean patientswith advanced GC. Overall, first-line palliative chemotherapy was found to maintain QOL, and most parameters showed an improvement compared with the baseline at some point during the course. Korean Cancer Association 2019-01 2018-10-19 /pmc/articles/PMC6333995/ /pubmed/30584995 http://dx.doi.org/10.4143/crt.2018.073 Text en Copyright © 2019 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Jin Won Kim, Jong Gwang Kang, Byung Woog Chung, Ik-Joo Hong, Young Seon Kim, Tae-You Song, Hong Suk Lee, Kyung Hee Zang, Dae Young Ko, Yoon Ho Song, Eun-Kee Baek, Jin Ho Koo, Dong‐Hoe Oh, So Yeon Cho, Hana Lee, Keun-Wook Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer |
title | Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer |
title_full | Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer |
title_fullStr | Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer |
title_full_unstemmed | Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer |
title_short | Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer |
title_sort | treatment patterns and changes in quality of life during first-line palliative chemotherapy in korean patients with advanced gastric cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333995/ https://www.ncbi.nlm.nih.gov/pubmed/30584995 http://dx.doi.org/10.4143/crt.2018.073 |
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