Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer

PURPOSE: The purpose of this study was to evaluate chemotherapy patterns and changes in quality of life (QOL) during first-line palliative chemotherapy for Korean patients with unresectable or metastatic/recurrent gastric cancer (GC). MATERIALS AND METHODS: Thiswas a non-interventional, multi-center...

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Autores principales: Kim, Jin Won, Kim, Jong Gwang, Kang, Byung Woog, Chung, Ik-Joo, Hong, Young Seon, Kim, Tae-You, Song, Hong Suk, Lee, Kyung Hee, Zang, Dae Young, Ko, Yoon Ho, Song, Eun-Kee, Baek, Jin Ho, Koo, Dong‐Hoe, Oh, So Yeon, Cho, Hana, Lee, Keun-Wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333995/
https://www.ncbi.nlm.nih.gov/pubmed/30584995
http://dx.doi.org/10.4143/crt.2018.073
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author Kim, Jin Won
Kim, Jong Gwang
Kang, Byung Woog
Chung, Ik-Joo
Hong, Young Seon
Kim, Tae-You
Song, Hong Suk
Lee, Kyung Hee
Zang, Dae Young
Ko, Yoon Ho
Song, Eun-Kee
Baek, Jin Ho
Koo, Dong‐Hoe
Oh, So Yeon
Cho, Hana
Lee, Keun-Wook
author_facet Kim, Jin Won
Kim, Jong Gwang
Kang, Byung Woog
Chung, Ik-Joo
Hong, Young Seon
Kim, Tae-You
Song, Hong Suk
Lee, Kyung Hee
Zang, Dae Young
Ko, Yoon Ho
Song, Eun-Kee
Baek, Jin Ho
Koo, Dong‐Hoe
Oh, So Yeon
Cho, Hana
Lee, Keun-Wook
author_sort Kim, Jin Won
collection PubMed
description PURPOSE: The purpose of this study was to evaluate chemotherapy patterns and changes in quality of life (QOL) during first-line palliative chemotherapy for Korean patients with unresectable or metastatic/recurrent gastric cancer (GC). MATERIALS AND METHODS: Thiswas a non-interventional, multi-center, prospective, observational study of 527 patients in Korea. QOL assessments were conducted using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaires (QLQ)-C30 and QLQ-STO22 every 3 months over a 12-month period during first-line palliative chemotherapy. The specific chemotherapy regimens were selected by individual clinicians. RESULTS: Most patients (93.2%) received combination chemotherapy (mainly fluoropyrimidine plus platinum) as their first-line palliative chemotherapy. The median progression-free survival and overall survival were 8.2 and 14.8 months, respectively. Overall, “a little” changes (differences of 5-10 points from baseline)were observed in some of the functioning or symptom scales; none of the QOL scales showed either “moderate” or “very much” change (i.e., ≥ 11 point difference from baseline). When examining the best change in each QOL domain from baseline, scales related to some aspects of functioning, global health status/QOL, and most symptoms revealed significant improvements (p < 0.05). Throughout the course of first-line palliative chemotherapy, most patients’ QOL was maintained to a similar degree, regardless of their actual response to chemotherapy. CONCLUSION: This observational study provides important information on the chemotherapy patterns and QOL changes in Korean patientswith advanced GC. Overall, first-line palliative chemotherapy was found to maintain QOL, and most parameters showed an improvement compared with the baseline at some point during the course.
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spelling pubmed-63339952019-01-22 Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer Kim, Jin Won Kim, Jong Gwang Kang, Byung Woog Chung, Ik-Joo Hong, Young Seon Kim, Tae-You Song, Hong Suk Lee, Kyung Hee Zang, Dae Young Ko, Yoon Ho Song, Eun-Kee Baek, Jin Ho Koo, Dong‐Hoe Oh, So Yeon Cho, Hana Lee, Keun-Wook Cancer Res Treat Original Article PURPOSE: The purpose of this study was to evaluate chemotherapy patterns and changes in quality of life (QOL) during first-line palliative chemotherapy for Korean patients with unresectable or metastatic/recurrent gastric cancer (GC). MATERIALS AND METHODS: Thiswas a non-interventional, multi-center, prospective, observational study of 527 patients in Korea. QOL assessments were conducted using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaires (QLQ)-C30 and QLQ-STO22 every 3 months over a 12-month period during first-line palliative chemotherapy. The specific chemotherapy regimens were selected by individual clinicians. RESULTS: Most patients (93.2%) received combination chemotherapy (mainly fluoropyrimidine plus platinum) as their first-line palliative chemotherapy. The median progression-free survival and overall survival were 8.2 and 14.8 months, respectively. Overall, “a little” changes (differences of 5-10 points from baseline)were observed in some of the functioning or symptom scales; none of the QOL scales showed either “moderate” or “very much” change (i.e., ≥ 11 point difference from baseline). When examining the best change in each QOL domain from baseline, scales related to some aspects of functioning, global health status/QOL, and most symptoms revealed significant improvements (p < 0.05). Throughout the course of first-line palliative chemotherapy, most patients’ QOL was maintained to a similar degree, regardless of their actual response to chemotherapy. CONCLUSION: This observational study provides important information on the chemotherapy patterns and QOL changes in Korean patientswith advanced GC. Overall, first-line palliative chemotherapy was found to maintain QOL, and most parameters showed an improvement compared with the baseline at some point during the course. Korean Cancer Association 2019-01 2018-10-19 /pmc/articles/PMC6333995/ /pubmed/30584995 http://dx.doi.org/10.4143/crt.2018.073 Text en Copyright © 2019 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Jin Won
Kim, Jong Gwang
Kang, Byung Woog
Chung, Ik-Joo
Hong, Young Seon
Kim, Tae-You
Song, Hong Suk
Lee, Kyung Hee
Zang, Dae Young
Ko, Yoon Ho
Song, Eun-Kee
Baek, Jin Ho
Koo, Dong‐Hoe
Oh, So Yeon
Cho, Hana
Lee, Keun-Wook
Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer
title Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer
title_full Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer
title_fullStr Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer
title_full_unstemmed Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer
title_short Treatment Patterns and Changes in Quality of Life during First-Line Palliative Chemotherapy in Korean Patients with Advanced Gastric Cancer
title_sort treatment patterns and changes in quality of life during first-line palliative chemotherapy in korean patients with advanced gastric cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333995/
https://www.ncbi.nlm.nih.gov/pubmed/30584995
http://dx.doi.org/10.4143/crt.2018.073
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